Patients with bile duct cancer might soon have an additional treatment available to them, thanks to a newly discovered tumor target.

Some bile duct cancers are driven by a mutated HER2 gene, which has also been implicated in cancers of the breast, esophagus and prostate, researchers report in a new study.

An experimental drug targeting HER2 mutations, zanidatamab, produced powerful ...

A clinical trial that's attempting to discover a cure for sickle cell disease has found a new gene therapy to be safe and successful in four patients.

Two of the patients were treated at Cleveland Clinic Children's in Ohio, and doctors there are hopeful that their positive results will be borne out in future research.

"New treatments like this are critical for people who have sickle...

A safe, generic diabetes pill can help people avoid long COVID, a new clinical trial shows.

Metformin cut the risk of long COVID by about 40% for patients who received a two-week course of the drug while battling their infection, the researchers reported.

The results were even more dramatic if COVID-19 patients began taking metformin soon after infection. Starting on the drug w...

For years, doctors have thought that a more extensive surgery that removes a wider swath of lymph nodes was the best option for certain patients with bladder cancer. Now, a new clinical trial is upending that belief.

Researchers found that the strategy -- known as extended lymphadenectomy -- was no better than standard surgery at prolonging patients' lives or the amount of time they live...

Once-a-day use of the targeted cancer pill Tagrisso (osimertinib) cut the five-year death rate in half for a subset of patients with early-stage lung cancer, a new clinical trial shows.

The results could have major implications for patients whose cancers carry a mutation in a gene known as EGFR, which is implicated in the out-of-control cellular growth driving a tumor. Tagrisso appears to...

A new study on using nitroglycerin patches to help women with frequent hot flashes caused by menopause has delivered mixed results.

The benefits of wearing these patches -- long used as chest pain medication -- were modest. They also were short-lived, with any benefits appearing to wear off over time, according to researchers from the University of California, San Francisco (UCSF).

An experimental targeted therapy can dramatically slow the progress of common slow-growing brain cancers, a new clinical trial finds.

The oral drug vorasidenib nearly tripled progression-free survival in patients with grade 2 gliomas compared to placebo, nearly 28 months versus 11 months, according to results presented Sunday at the American Society of Clinical Oncology (ASCO) annual meet...

A new liver dialysis device might soon be able to save patients on the edge of death from liver failure, early clinical trial results show.

The DIALIVE device safely improved organ function and alleviated symptoms in patients with acute-on-chronic liver failure, compared with others receiving standard care, the researchers reported.

If the device proves out in a larger trial, it cou...

A common test for lung function may be missing lung problems in Black men, leading to under-diagnosis and insufficient care.

A new study from the University of Pennsylvania estimates that as many as 40% more Black male patients would have been diagnosed with breathing problems if racial bias hadn't been built into diagnosing software.

At issue is part of a long-held assumption th...

An extended-release version of a Parkinson's disease drug could provide more stable relief for patients with the movement disorder, new clinical trial data show.

The new formulation of levodopa, called IPX203, extended the duration of patients' "on time" -- the amount of time the medication is working and symptoms are lessened, researchers reported this week at the American Academy of Ne...

Whether the gender of a blood donor could affect the recipient's survival was an unanswered question in medicine. Until now.

"Some observational studies had suggested female donor blood might be linked with a higher risk of death among recipients compared to male donor blood, but our clinical trial found that isn't the case,"co-lead author